###################################################### ##### Sequences and other information for the PX Domain ##### Prepared as a part of MeTaDoR (http://proteomics.bioengr.uic.edu/metador) ##### By Nitin Bhardwaj (Dr Hui Lu's Lab at the Univ of Illinois at Chicago) ##### As of May 2007 ###################################################### ###################################################### ##### README ##### First column contains the name of the host-protein ##### Second column contains the species name. 'Human', 'Yeast' and ##### 'Mouse' Have been indicated and others have been indicated by 'Others' ##### Third column indicates membrane-binding (indicated by 1) or ##### non-membrane-binding (indicated by 0) behavior of the protein. ##### Fourth and fifth columns state the function and subcellular location ##### of the protein as given in the Swiss-Prot/Uniprot database, respectively (wherever available). ##### Sixth and subsequent columns provide the sequences of all occurrence of ##### the domain in the host protein. ###################################################### ATG20_ASHGO Yeast 1 FUNCTION: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Endosome; endosomal membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). GEQGRVRILEASKVSEGQGRSYITYTISYRDRVVRRRYSEFESLRKILIKLFPMTLIPPIPEKQSLTSYGKSIAGSNANYVLPSEAAGCDLAVSVINGSVNLNDQKMIRHRIRMLTSFLNRLLQNEEVTKTSIIGDFLDPNNANW ATG20_CANAL Yeast 1 FUNCTION: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Endosome; endosomal membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). IQITEAGNSNEGMSNSSKKYTVYTIKLINLEDPNNDILTRRRYSDFESLRDVLTKIFPLIVIPPIPPKNYFDFSMLNGLVGSNHENSSLSVAGSNGNSGGSGGGGASGGAGSGSGNGSIITSPKTYSYINSTHLTKGKLIEHRKRLLTNFLNNCLEIKQIRSLEFFAKFLDPNANWG ATG20_CANGA Yeast 1 FUNCTION: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Endosome; endosomal membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). KSGKHVRILEAKKVSEGQSRTFVAYFIKYNGHMVRRRYSDFESLRSILVKLFPLMVIPPIPEKEGLKSYSKAIAGLKHAKYILPSEQTDSVDLSLSIIDQSVSDKEENIIRHRVRILTKFLNRLLDNTDISSTSLIEDFLNPNNSNW ATG20_DEBHA Yeast 1 FUNCTION: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Endosome; endosomal membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). NDPNLQINVISSERMINSSVVAYSIELSSFDDNRMIVKRRYSEFKSLRDNLQILFPTLVIPPIPEKHTLFTYLINSIDNSKELNIIETRKRCFANFLKDIIFDSNVALKSCVLVHKFLDPNYEL ATG20_KLULA Yeast 1 FUNCTION: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Endosome; endosomal membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). EGKKRAQILEASKVSEGQGRTYIAYAIKYGDSIVKRRYSDFESLRKVLVKLFPISLIPPIPEKQSLKSYGKAMTYSKSSYLLPTESGDSVDLSLSVINGPVTTNDEKLIRHRIRMLTSFLNRLLKNQEITKTSIVYDFLDPNNKNW ATG20_YEAST Yeast 1 FUNCTION: Required for cytoplasm to vacuole transport (Cvt) and pexophagy. Involved in proper sorting of the v-SNARE protein SNC1. SUBCELLULAR LOCATION: Cytoplasm. Membrane; peripheral membrane protein. Endosome; endosomal membrane; peripheral membrane protein. Endosome and other perivacuolar punctate structures. MNGETSASEEPSVSNRKKSARIHILEAKRVSEGQGRAYIAYVIQFENSTVQRRYSDFESLRSILIRLFPMTLIPPIPEKQSIKNYGKSITGSSSKYLLPSEGSGSVDLSLSVIHASVNNSDEKLIRHRIRMLTEFLNKLLTNEEITKTSIITDFLDPNNHNW P3C2G_HUMAN Human 1 " FUNCTION: In vitro, phosphorylates PtdIns and PtdIns4P but not PtdIns(4,5)P2 (By similarity)." SUBCELLULAR LOCATION: Membrane; peripheral membrane protein (By similarity). LLSTTRSIERAILGFSKKSSNLYLIQVTHSNNETSLTEKSFEQFSKLHSQLQKQFASLTLPEFPHWWHLPFTNSDHRRFRDLNHYMEQILNVSHEVTNSDCVLSFFLSEAVQQ P3C2G_MOUSE Mouse 1 " FUNCTION: In vitro, phosphorylates PtdIns and PtdIns4P but not PtdIns(4,5)P2." SUBCELLULAR LOCATION: Membrane; peripheral membrane protein. LNKTRTIQRVTILGFSKTHSNLYLMEVTCSDNRRSLTKKSFEQFYRLHSQMQKQFSSLALPEFPHWWHLPFTDSDHKRIRDLSHYVEQVLRGSYEVANSDCVLSFFLSEHIQP P3C2G_RAT Others 1 " FUNCTION: In vitro, phosphorylates PtdIns and PtdIns4P but not PtdIns(4,5)P2." SUBCELLULAR LOCATION: Membrane; peripheral membrane protein (By similarity). LNKTRTIQRVTILGFSKTHSNLYLIEVTRSDNRKNLAKKSFEQFYRLHSQIQKQFPLLTLPEFPHWWHLPFTDSHHERIRDLSHYVEQVLHGSYEVANSDCVLSFFLSEHIQQ PLD2_HUMAN Human 1 FUNCTION: May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity). SUBCELLULAR LOCATION: Membrane; peripheral membrane protein (By similarity). VTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVLMSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLS PLD2_MOUSE Mouse 1 FUNCTION: May have a role in signal-induced cytoskeletal regulation and/or endocytosis. SUBCELLULAR LOCATION: Membrane; peripheral membrane protein. VIAQVVGTERYTSGSKVGTCTLYSVRLTHGDFTWTTKKKFRHFQELHRDLQRHKVLMSLLPLARFAVTHSPAREAAAEDIPSLPRGGSEGSARHTASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLS PLD2_RAT Others 1 FUNCTION: May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity). SUBCELLULAR LOCATION: Membrane; peripheral membrane protein (By similarity). VIAQVVGTERYTSGSKVGTCTLYSVRLTHGDFTWTTKKKFRHFQELHRDLQRHKVLMSLLNLARFAAAHSPAREAANENIPSLPRGGSEGSARHTASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLS PXK_RAT Others 1 " FUNCTION: Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity (By similarity)." SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane; peripheral membrane protein (By similarity). Also associates with the plasma membrane (By similarity). LDDTVPLTAAVEASQSLQSHTEYIIRVQRGISAENSWQIVRRYSDFDLLNNSLQITGLSLPLPPKKLIGNMDREFIAERQKGLQNYLNVIMANHVLSNCELLKKFLDPNNYSA SNX41_ASHGO Yeast 1 FUNCTION: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). SUBCELLULAR LOCATION: Endosome; endosomal membrane; peripheral membrane protein (By similarity). Intracellular membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). AEGSLGALRIVDAGQYKDTFGNYAIGYTIAYEGRQVTRRYSEFDSLRQALARLLPTVIIPPIPSKHPLIRYFLNPLNAENDIRIIEKRRRLLSRFLNNCHDITDIREHTVFQKFLNPEYIW SNX41_CANAL Yeast 1 FUNCTION: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). SUBCELLULAR LOCATION: Endosome; endosomal membrane; peripheral membrane protein (By similarity). Intracellular membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). NDSQLQVDIINSEKLVNSSVIVYTIELSSPTTKIVVKRRYSEFKSLRDNLLKLFPTLIIPPIPEKHSILSYLLNTINHSHEISIIEMRKRYFKMFLDDLIFQSDYKLKNCPLLHKFFDPNYELC SNX41_CRYNE Others 1 FUNCTION: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). SUBCELLULAR LOCATION: Endosome; endosomal membrane; peripheral membrane protein (By similarity). Intracellular membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). GEQVHIVDALKTTEGGTASYITYVIRLGTHTVRRRYSAFLSLHQSLTGLYPVLIIPPIPSKQSLTDYAVKGQSKAREDATIIARRKRLLEDFLQRLIRHPILGGEHVLHRFLEEDVSW SNX41_DEBHA Yeast 1 FUNCTION: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). SUBCELLULAR LOCATION: Endosome; endosomal membrane; peripheral membrane protein (By similarity). Intracellular membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). MQITKAGNSNEGMINTLKTYIVYSIQLINNDDPSDEIQTRRRYSDFESLRDVLKKIFPLIIIPPIPPKNYFKFSMLNDLVSGNILQSSNTSSNNSTGANTSTNTTNGLGSNSTNYSYINSTHLNKNKLIEHRKRLLSNFLNNCLAIPQIRNLEFFAKFLDPNANWT SNX41_EMENI Others 1 FUNCTION: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). SUBCELLULAR LOCATION: Endosome; endosomal membrane; peripheral membrane protein (By similarity). Intracellular membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). PDMPILITDAGKNHEGGGSFIVYTIRTGDLEVRRRYSEFASLRQTLVSLHPTLIVPPIPEKHSMADYAAKPTKAKEDAGIIDLRKRMLAVFLNRCRRMKEIREDGVWWRFLDPNVSWS SNX41_KLULA Yeast 1 FUNCTION: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). SUBCELLULAR LOCATION: Endosome; endosomal membrane; peripheral membrane protein (By similarity). Intracellular membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). QGKNPEVIRIVDAGQYRDIYGKYAIGYKIEFGGIVVTRRYSEFDSLRQSLCRLLPTIIIPPIPSKHPIIKYLFNPLHAKKDIKIIERRQRLLSRFLNNCHKVREIRNHIVFQKFLNPEYFW SNX41_NEUCR Others 1 FUNCTION: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). SUBCELLULAR LOCATION: Endosome; endosomal membrane; peripheral membrane protein (By similarity). Intracellular membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). PELPILITEAGKSQESGGRFIVYTIKTGDLTVRRRYSEFASLRDALTRLHPTLVIPPIPEKHTMADYAANPTNAKQDQQIIDLRKRMLAVFLNRCRRMEQVRTDGVWWRFLDPNSSW SNX41_SCHPO Yeast 1 FUNCTION: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). SUBCELLULAR LOCATION: Endosome; endosomal membrane; peripheral membrane protein (By similarity). Intracellular membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). ALDPNGIVITGAMKAESGSHIVYIIKLQDSEIHHRYSEFASLRVQLSRLYPTCLVPPLPDKHKIMDYLINVTKNQRMSRMLEERKRLLQLFLRRVAQHPILGLSEVFRKFLSRHVSW SNX41_YARLI Others 1 FUNCTION: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). SUBCELLULAR LOCATION: Endosome; endosomal membrane; peripheral membrane protein (By similarity). Intracellular membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). NQNDTAHEATNERTTTASQSNIPPIEIIEANKNHEGTSRGFITYTIRVGDVSVRRRYSEFESLRTTLTRMFPTLIVPPIPEKHSITDYAVAPTKAREDKDMIEHRQRMLQVFLNRCRNLPQISNCIVFQRFLDPHASWS SNX41_YEAST Yeast 1 FUNCTION: Involved in proper sorting of the v-SNARE protein SNC1. SUBCELLULAR LOCATION: Perivacuolar punctate structures and endosome. VSLSMSTTATISKFTPHDMNGTQQIQIIDAGDFKDPWGKHAIGYVILYENNKIIRRYSEFHSLRQSLTRLLPTIIIPPIPSKHSLLKYIWSPINAANDSKIISTRKKMLNSFLSNCLNIQEISNDIVFQKFLNPEFNW SNX4_ASHGO Yeast 1 FUNCTION: Required for cytoplasm to vacuole transport (Cvt) and pexophagy. Involved in the fusion between the pexophagosome and the vacuole. Also involved in the separation or division of vacuoles throughout the entire life cycle of the cells (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Endosome; endosomal membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). FIIVSDPQKQRGDKSSSGSYVTYQISSKPATEGDKRSGEDDITVVHRRYSDFVLLYQILANDYPACIVPPLPDKKVLNYLDRFSQSFTQKRCHSLQNFLQRLAQHPVLSQSKILHTFLVSSDWDA SNX4_ASPFU Others 1 FUNCTION: Required for cytoplasm to vacuole transport (Cvt) and pexophagy. Involved in the fusion between the pexophagosome and the vacuole. Also involved in the separation or division of vacuoles throughout the entire life cycle of the cells (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Endosome; endosomal membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). VLECRVDSPLKENDGTKDAYISYLVTTHTDFKSFQKPDFAVRRRFTDFYFLYKTLYREYPACAVPPLPEKHKMEYVTGDRFGPEFTSRRAWSLHRFLKRLTLHPVLRRAPLLAIFLESPDWNA SNX4_CANAL Yeast 1 FUNCTION: Required for cytoplasm to vacuole transport (Cvt) and pexophagy. Involved in the fusion between the pexophagosome and the vacuole. Also involved in the separation or division of vacuoles throughout the entire life cycle of the cells (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Endosome; endosomal membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). SIKTTVTHPNRDLDTASKPFISYLVTTTTDNPSILKLTKEKKPKQGEEYLTFSVRRRYGDFRYLYESLSNDFPTVMIPPLPSKSNFKYLTGDTFSSEFVHKRLHSLDRFIRFILQHKILSQSSIFHLFISNSNDW SNX4_CANGA Yeast 1 FUNCTION: Required for cytoplasm to vacuole transport (Cvt) and pexophagy. Involved in the fusion between the pexophagosome and the vacuole. Also involved in the separation or division of vacuoles throughout the entire life cycle of the cells (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Endosome; endosomal membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). LEILVSDPQKRAGEAGLGPYVSYQISTRTDNPSYHGNQKASFDDIIVVHRRYNDVVLLHDILQNDHPTCIIPPLPDKKVLQYIAGDRFGRRFTQRRCHSLQNFLRRVSQHPILSTSKVLEIFLVGNEWDT SNX4_CRYNE Others 1 FUNCTION: Required for cytoplasm to vacuole transport (Cvt) and pexophagy. Involved in the fusion between the pexophagosome and the vacuole. Also involved in the separation or division of vacuoles throughout the entire life cycle of the cells (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Endosome; endosomal membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). WMDVQVREPAKEHEGSKDMYVSYAVKTETSLPTFRKPLTVVRRRFQDFVFLREHLVKNFPACVVPPIPDKHRLEYIKGDRFSPEFVERRRLDLQRFADRIARHPVLQRSQLVNDFLQSTEWSV SNX4_DEBHA Yeast 1 FUNCTION: Required for cytoplasm to vacuole transport (Cvt) and pexophagy. Involved in the fusion between the pexophagosome and the vacuole. Also involved in the separation or division of vacuoles throughout the entire life cycle of the cells (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Endosome; endosomal membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). EINVVVTSPLRDLDSSSKPYISYLLTTATNHPSVMKLSTVKKEQGKEVVEITARRRYGDFRFLFDCLSNDHPEVMMPPLPSKLNFKYLTGDTFSTEFVHKRLHSLDRFVRFITCHKVLSQLSIFHLFVSDSADW SNX4_EMENI Others 1 FUNCTION: Required for cytoplasm to vacuole transport (Cvt) and pexophagy. Involved in the fusion between the pexophagosome and the vacuole. Also involved in the separation or division of vacuoles throughout the entire life cycle of the cells (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Endosome; endosomal membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). VLECRVDTPIKENDGTKDAYISYLVTTHTDFKSFQKADFTVRRRFTDFVFLYKTLYREYPACAVPPLPDKHKMEYVRGDRFGAEFTTRRAWSLHRFLKRLTLHPVLRRAPLLAIFLESPDWNA SNX4_KLULA Yeast 1 FUNCTION: Required for cytoplasm to vacuole transport (Cvt) and pexophagy. Involved in the fusion between the pexophagosome and the vacuole. Also involved in the separation or division of vacuoles throughout the entire life cycle of the cells (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Endosome; endosomal membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). KILSVLVSDPQKQKTHSQTYITYQVSTKIDGKDEPNCVVRRYNDFVLLHQILINDHPALLVPPLPDKKVLNYLSGDRFSHSFTQKRCRSLQTFMRRLLSHSELSKSRILETFLTSTDWDV SNX4_MAGGR Others 1 FUNCTION: Required for cytoplasm to vacuole transport (Cvt) and pexophagy. Involved in the fusion between the pexophagosome and the vacuole. Also involved in the separation or division of vacuoles throughout the entire life cycle of the cells (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Endosome; endosomal membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). VLECNVSSPLKENDGTKDAFVSYLVTTHTTFADFQKPDASVRRRFTDFVFLFKTLSREYPASAVPPLPDKQRMEYVRGDRFGNDFTSRRAYSLRRFLARCALHPVLRRSAILHTFLESPDWNA SNX4_NEUCR Others 1 FUNCTION: Required for cytoplasm to vacuole transport (Cvt) and pexophagy. Involved in the fusion between the pexophagosome and the vacuole. Also involved in the separation or division of vacuoles throughout the entire life cycle of the cells (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Endosome; endosomal membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). ILDCTVSDPHKENDGTKDAYVSYLITTNTTFPSFQKPKTTVRRRFTDFVFLYKVLCRDYQACAVPPLPDKQRMEYVRGDRFGTDFTARRAYSLQRFLARLALHPILRKADILHAFLESPDWNA SNX4_PICPA Yeast 1 FUNCTION: Required for glucose-induced micropexophagy and ethanol- induced macropexophagy. Involved in the fusion between the pexophagosome and the vacuole. Also involved in the separation or division of vacuoles throughout the entire life cycle of the cells. SUBCELLULAR LOCATION: Cytoplasm. Membrane; peripheral membrane protein. Vacuole; vacuolar membrane; peripheral membrane protein. Vacuolar and other perivacuolar punctate structures. VYIRSKVSQPLKESDGQNFYISYLIETETNEPGLAKTKLKVRRRFSDSNFLYNCLANDFPTSIIPPLPNKQRLEYIKGDRFGEYFTTKRSIALNNFLNRISKHPLLKQAKIYHIFLEDSVNW SNX4_SCHPO Yeast 1 FUNCTION: Required for cytoplasm to vacuole transport (Cvt) and pexophagy. Involved in the fusion between the pexophagosome and the vacuole. Also involved in the separation or division of vacuoles throughout the entire life cycle of the cells (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; peripheral membrane protein (By similarity). Endosome; endosomal membrane; peripheral membrane protein (By similarity). Endosome and other perivacuolar punctate structures (By similarity). FLQCLVTEPRKELQGSRDTHVSYLIITKTNLSIFTRAECKVRRRFSDFVKLQEILSRMNEDCVVPPLPAKHKLEYIKGGRFSDNFINRRAKLLNRYITRCALHPVLHQSPHFIAFLENPNWNN SNX4_YEAST Yeast 1 FUNCTION: Required for cytoplasm to vacuole transport (Cvt) and pexophagy. Involved in proper sorting of the v-SNARE protein SNC1. SUBCELLULAR LOCATION: Cytoplasm. Membrane; peripheral membrane protein. Endosome; endosomal membrane; peripheral membrane protein. Endosome and other perivacuolar punctate structures. Associates to phosphatidylinositol 3-phosphate; necessary for peripheral membrane localization to the perivacuolar punctate structures. EIIVSDPQKRTGDPGSSSGYVSYQISTKTNNTSFYDNRGDPESIIVVHRRYSDLLLLHDILLNRFPTCIIPPLPDKKVFQYIAGDRFSQRFTQKRCHSLQNFLRRVSLHPDLSQSKVFKTFLVSKDWES KS6C1_HUMAN Human 1 FUNCTION: May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell. SUBCELLULAR LOCATION: Cytoplasm. Membrane-associated; also found in some small dot-like or ring-shaped early endosome structures. SADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDFFKGGIIND KS6C1_MOUSE Mouse 1 FUNCTION: May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Membrane-associated; also found in some small dot-like or ring-shaped early endosome structures (By similarity). SADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWRRYSDFKKLHRELWQIHRNAFRHSELFPPFAKGTVFGRFDKTVIEERRQCAEDLLQFSANIPALYNSRQLQDFFKGGVISD NCF1_BOVIN Others 1 " FUNCTION: NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production)." SUBCELLULAR LOCATION: Cytoplasm. HFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKILKEMFPIEAGDINPENRIIPHLPAPRWYDGQRVAESRQGTLTEYCSTLMSLPVKISRCPHLLNFFKVRPDDL NCF1_HUMAN Human 1 " FUNCTION: NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production)." SUBCELLULAR LOCATION: Cytoplasm. TFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCSTLMSLPTKISRCPHLLDFFKVRPDDL NCF1_MOUSE Mouse 1 " FUNCTION: NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production)." SUBCELLULAR LOCATION: Cytoplasm. TFIRHIALLGFEKRFIPSQHYVYMFLVKWQDLSEKVVYRKFTEIYEFHKMLKEMFPIEAGEIHTENRVIPHLPAPRWFDGQRAAESRQGTLTEYFNGLMGLPVKISRCPHLLDFFKVRPDDL NOXO1_HUMAN Human 1 " FUNCTION: Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity." SUBCELLULAR LOCATION: Isoform 3 associates with the plasma membrane in a lipid-dependent manner. MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEAGLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQPLDL NOXO1_MOUSE Mouse 1 " FUNCTION: Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity." SUBCELLULAR LOCATION: Cell membrane (By similarity). Associates with the plasma membrane in a lipid-dependent manner (By similarity). MASPRHPVSAHAVALVQMDRLQTFAFSVCWSDNSDTFVRRSWDEFRQLQKTLKKTFPVEAGLLRRSEQVLPKLPDAPLLTRRGHTGRGLVRLRLLDTYVQALLATSEHILRSSALHGFFVPKPLDL P3C2A_HUMAN Human 1 " FUNCTION: Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2. May play a role in clathrin-coated endocytic vesicle formation and EGF signaling cascade. May be involved in mitosis and UV-induced damage response. May be a downstream effector in insulin signaling cascade." " SUBCELLULAR LOCATION: Ref.2, Ref.5: Cell membrane. Golgi apparatus. Clathrin-coated vesicles. Ref.4: Nuclear. Cytoplasm. Associated with RNA-containing structures. Ref.6, mainly: Cytoplasm." GRIKEVSVFTYHKKYNPDKHYIYVVRILWEGQIEPSFVFRTFVEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDE P3C2A_MOUSE Mouse 1 " FUNCTION: Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2. May play a role in clathrin-coated endocytic vesicle formation and EGF signaling cascade. May be involved in mitosis and UV-induced damage response (By similarity). May be a downstream effector in insulin signaling cascade." QDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGHLEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLR P3C2A_PONPY Others 1 " FUNCTION: Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2. May play a role in clathrin-coated endocytic vesicle formation and EGF signaling cascade. May be involved in mitosis and UV-induced damage response. May be a downstream effector in insulin signaling cascade (By similarity)." GRIKEVSVFTYHKKYNPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDE P3C2B_HUMAN Human 1 " FUNCTION: Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades." " SUBCELLULAR LOCATION: Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis." GRISDVFLCRHEKIFHPNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGEAVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRDE PLD1_CRIGR Others 1 " FUNCTION: Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity)." " SUBCELLULAR LOCATION: Perinuclear regions: endoplasmic reticulum, Golgi apparatus and late endosomes (By similarity)." IKAQVLEVERFTSTTRVPSINLYTIELTHGEFTWQVKRKFKHFQEFHRELLKYKAFIRIPIPTKRHTFRRQNVKEEPREMPSLPRSSENTIQEEQFFGRRKQLEDYLTKILKMPMYRNYHATTEFLDVSQLS PLD1_HUMAN Human 1 " FUNCTION: Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity)." " SUBCELLULAR LOCATION: Perinuclear regions: endoplasmic reticulum, Golgi apparatus and late endosomes (By similarity)." IKAQVLEVERFTSTTRVPSINLYTIELTHGEFKWQVKRKFKHFQEFHRELLKYKAFIRIPIPTRRHTFRRQNVREEPREMPSLPRSSENMIREEQFLGRRKQLEDYLTKILKMPMYRNYHATTEFLDISQLS PLD1_MOUSE Mouse 1 " FUNCTION: Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic." " SUBCELLULAR LOCATION: Perinuclear regions: endoplasmic reticulum, Golgi apparatus and late endosomes." IKAQVLEVERFTSTSRVPSINLYTIELTHGEFTWQVKRKFKHFQEFHRELLKYKAFIRIPIPTKRHTFRRQNVKEEPREMPSLPRSSENAIQEEQFFGRRKQLEDYLTKILKMPMYRNYHATTEFLDVSQLS PLD1_RAT Others 1 " FUNCTION: Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity)." " SUBCELLULAR LOCATION: Perinuclear regions: endoplasmic reticulum, Golgi apparatus and late endosomes (By similarity)." VKAQVLEVERFTSTSRMPSVNLYTIELTHGEFTWQVKRKFKHFQEFHRELLKYKAFIRIPIPTKRHTFRRQNVKEEPREMPSLPRSSENAIQEEQFFGRRKQLEDYLTKILKMPMYRNYHATTEFLDVSQLS PXK_HUMAN Human 1 " FUNCTION: Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity." SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; peripheral membrane protein. Also associates with the plasma membrane. Isoform 3 is present throughout the cell. LDDTVPLTAAIEASQSLQSHTEYIIRVQRGISVENSWQIVRRYSDFDLLNNSLQIAGLSLPLPPKKLIGNMDREFIAERQKGLQNYLNVITTNHILSNCELVKKFLDPNNYSA PXK_MOUSE Mouse 1 " FUNCTION: Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity." SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; peripheral membrane protein. Also associates with the plasma membrane. LDDTVPLTAAVEASQSLQSHTEYIIRVQRGISAENSWQIVRRYSDFDLLNNSLQITGLSLPLPPKKLIGNMDREFIAERQRGLQNYLNVIMANHVLSNCELLKKFLDPNNYSA SGK3_HUMAN Human 1 FUNCTION: Involved in the activation of potassium channels. Mediates cell IL-3-dependent survival signals (By similarity). SUBCELLULAR LOCATION: Localized in vesicle-like structures and in the early endosome (By similarity). SCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNTLKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH SGK3_MOUSE Mouse 1 FUNCTION: Involved in the activation of potassium channels (By similarity). Mediates cell IL-3-dependent survival signals. Can inhibit pro-apoptotic FOXO3A in vitro. SUBCELLULAR LOCATION: Localized in vesicle-like structures and in the early endosome. SCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNSLKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPRH SNX10_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). FVSVWVRDPRIQKEDFWHSYIDYEICIHTNSMCFTMKTSCVRRRYREFVWLRQRLQSNALLVQLPELPSKNLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSSLHLFLQSHLNS SNX10_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). FVSVWVRDPRIQKEDFWHSYIDYEICIHTNSMCFTMKTSCVRRRYREFVWLRQRLQSNALLVQLPELPSKNLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSSLHLFLQSHLNS SNX11_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). VITVRVQDPRVQNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRKQLQRNAGLVPVPELPGKSTFFGTSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSV SNX11_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). VITVRVQDPRVQNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRKQLQRNAGLVPVPELPGKSTFFGGSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSV SNX12_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). NFLEIDIFNPQTVGVGRARFTTYEVRMRTNLPIFKLKESCVRRRYSDFEWLKNELERDSKIVVPPLPGKALKRQLPFRGDEGIFEESFIEERRQGLEQFINKIAGHPLAQNERCLHMFLQEEAID SNX12_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). NFLEIDIFNPQTVGVGRARFTTYEVRMRTNLPIFKLKESCVRRRYSDFEWLKNELERDSKIVVPPLPGKALKRHPFRGDEGIFEESFIEERRQGLEQFINKIAGHPLAQNERCLHMFLQEEAID SNX13_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking. Act as a GAP for Galphas. ANIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTTRIVDDFGTHLRVFRKAQQKITEKDDQVKGTAEDLVDTFFEVEVEMEKEVCRDLVCTSPKDEEGFLRDLCEVLLYLLLPPGDFQNKIMRYFVREILARGILLPLINQLSDPDYINQYVIWMIRDSN YADYDPYAVAGVCNDHGKTYALYAITVHRRNLNSEEMWKTYRRYSDFHDFHMRITEQFESLSSILKLPGKKTFNNMDRDFLEKRKKDLNAYLQLLLAPEMMKASPALAHYVYDFLENKAYSK SNX13_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking. Act as a GAP for Galphas (By similarity). ANIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTTRIVDDFGTHLRVFRKAQQRVTEKDDQVKGTAEDLVETFFEVEVEMEKDVCRDLVCTSPKDEEGFLRDLCEVLLYLLLPPGDFQSKIMRYFVREILARGILLPLINQLSDPDYINQYVIWMIRDSN VQLHAYISDTGVCNDHGKTYALYAITVHRRNLNTEEMWKTYRRYSDFHDFHMRITEQFENLSSILKLPGKKTFNNMDRDFLEKRKKDLNAYLQLLLTPEMMKASPALAHCVYDFLENKAYSK SNX14_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). YKPKQLGLQELFPQGHSCAVCGKVKCKRHRPSLLLENYQPWLDLKISSKVDASLSEVDIPSIITKKLLKAAMKHIEVIVKARQKVKNTEFLQQAALEEYGPELHVALRSRRDELHYLRKLTELLFPYILPPKATDCRSLTLLIREILSGSVFLPSLDFLADPDTVNHLLIIFIDDSP PYVDFFEDPSSERKEKKERIPVFCIDVERNDRRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGAFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLLQHPELSNSQLLADFLSPNGGET SNX14_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). SSKVDASLSEVLELVLENFVYPWYRDVTDDESFVDELRITLRFFASVLVRRIHKVDIPSIITKKLLKAAMKHIEVIVKARQKVKNTEYLQQAALEEYGPELHVALRSRRDELQYLRKLTELLFPYILPPKATDCRSLTLLIREILSGSVLLPSLDFLADPDTVNHLLIIFIDDSP PYVDFFEDPSSERKEKKERIPVFCIDVERNDRRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGTFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLVQHPELSNSQLLADFLSPNGGET SNX15_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTR SNX15_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity). MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDIKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVPIPALNNSPQLKEFFRGGEVTR SNX15_RAT Others 1 FUNCTION: May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity). MSRRAKKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDIKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVPIPALNNSPQLKEFFRGGEVTR SNX16_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). DRPSTPTILGYEVMEERAKFTVYKILVKKTPEESWVVFRRYTDFSRLNDKLKEMFPGFRLALPPKRWFKDNYNADFLEDRQLGLQAFLQNLVAHKDIANCLAVREFLCLDDPPG SNX16_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). DRPSTPTILGYEVMEERAKFTVYKILVKKSPEESWVVFRRYTDFSRLNDKLKEMFPGFRLALPPKRWFKDNYNAEFVEDRQLGLQAFLQNLVAHKDIANCLAVREFLCLDDPPG SNX16_RAT Others 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). DRPSTPTILGYEVMEERAKFTVYKILVKKSPEESWVVFRRYTDFSRLNDKLKEMFPGFRLALPPKRWFKDNYNADFLEDRQLGLQAFLQNLVAHKDIANCLAVREFLCLDDPPG SNX17_BOVIN Others 1 FUNCTION: May be involved in protein trafficking (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Associated with early endosomes (By similarity). MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQET SNX17_BRARE Others 1 FUNCTION: May be involved in protein trafficking (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Associated with early endosomes (By similarity). MHFSIPETEVRSDENGSSYVAYNIHVNGVLHCRVRYSQLLGLHEQIKKEYGNNVVPAFPPKKIFTLTPAEVDQRREQLEKYMQAVRQDPILGSSEMFNSFLRKAQQET SNX17_HUMAN Human 1 FUNCTION: May be involved in protein trafficking. SUBCELLULAR LOCATION: Cytoplasm. Associated with early endosomes. MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQET SNX17_MOUSE Mouse 1 FUNCTION: May be involved in protein trafficking. SUBCELLULAR LOCATION: Cytoplasm. Associated with early endosomes. MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVVPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQET SNX17_PONPY Others 1 FUNCTION: May be involved in protein trafficking (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Associated with early endosomes (By similarity). MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLREQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQET SNX17_RAT Others 1 FUNCTION: May be involved in protein trafficking (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Associated with early endosomes (By similarity). MHFSIPETESRSGDSGGSTYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQET SNX18_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). FQCTIDDPTKQTKFKGMKSYISYKLVPTHTQVPVHRRYKHFDWLYARLAEKFPVISVPHLPEKQATGRFEEDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPSSTD SNX18_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). FQCTIDDPTKQTKFKGMKSYISYKLVPTHTQVPVHRRYKHFDWLYARLAEKFPVISVPHLPEKQATGRFEEDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPSSTD SNX19_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). ERQLEREINRTIQMIIRDFVLSWYRSVSQEPAFEEEMEAAMKGLVQELRRRMSVMDSHAVAQSVLTLCGCHLQSYIQAKEATAGKNGPVEPSHLWEAYCRATAPHPAVHSPSAEVTYTRGVVNLLLQGLVPKPHLETRTGRHVVVELITCNVILPLISRLSDPDWIHLVLVGIFSKAR LRITGTITAREHSGTGFHPYTLYTVKYETALDGENSSGLQQLAYHTVNRRYREFLNLQTRLEEKPDLRKFIKNVKGPKKLFPDLPFGNMDSDRVEARKSLLESFLKQLCAIPEIANSEEVQEFLALNTDAR SNX1_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. FDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPR SNX1_MACFA Others 1 FUNCTION: May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (By similarity). FDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPR SNX1_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. FDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPMFRSRQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPR SNX1_PONPY Others 1 FUNCTION: May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (By similarity). FDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYIQRIVNHPTMLQDPDVREFLEKEELPR SNX1_RAT Others 1 FUNCTION: May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. FDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPMFRSRQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPR SNX20_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). VRLLFEIASARIEERKVSKFVMYQVVVIQTGSFDSDKAVVERRYSDFERLQKALLKRFGPELEDVAFPRKRLTGNLSAETICERRRELREYLRLLYAVRAVRRSREFLDFLTRPELRE SNX21_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). QRLLFEVTSANVVKDPPSKYVLYTLAVIGPGPPDCQPAQISRRYSDFERLHRNLQRQFRGPMAAISFPRKRLRRNFTAETIARRSRAFEQFLGHLQAVPELRHAPDLQDFFVLPELRR SNX22_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). MLEVHIPSVGPEAEGPRQSPEKSHMVFRVEVLCSGRRHTVPRRYSEFHALHKRIKKLYKVPDFPSKRLPNWRTRGLEQRRQGLEAYIQGILYLNQEVPKELLEFLRLRHFPTDPKASN SNX23_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking. Probable microtubule-dependent motor protein (By similarity). DPIKISIPRYVLCGQGKDAHFEFEVKITVLDETWTVFRRYSRFREMHKTLKLKYAELAALEFPPKKLFGNKDERVIAERRSHLEKYLRDFFSVMLQSATSPLHINKVGLTLSKHT SNX24_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). MEVYIPSFRYEESDLERGYTVFKIEVLMNGRKHFVEKRYSEFHALHKKLKKCIKTPEIPSKHVRNWVPKVLEQRRQGLETYLQAVILENEELPKLFLDFLNVRHLPSLPKAESCGSFDETESEES SNX24_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). MEVYIPSFRHEDSDLERGYTVFKIEVLMNGRKHFVEKRYSEFHALHKKLKKCIKTPEIPSKHVRNWVPKVLEQRRQGLETYLQAVILENEELPKLFLDFLNVRHLPSLPKAESCGSFDETESEES SNX24_RAT Others 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). MEVYIPSFRHEDSDLERGYTVFKIEVLMNGRKHFVEKRYSEFHALHKKLKKCIKTPEIPSKHVRNWVPKVLEQRRQGLETYLQAVILENEELPKLFLDFLNVRHLPSLPKAESCGSFDETESEES SNX25_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). GMWKASITSGEVTEENGEQLPCYFVMVSLQEVGGVETKNWTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSIDQKFMEKSKNQLNKFLQNLLSDERLCQSEALYAFLSPSPDYL SNX27_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). QAVPISVPRYKHVEQNGEKFVVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIMQEFLSESDENY SNX2_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking. FDIEIGVSDPEKVGDGMNAYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLESSELPR SNX2_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking. FDIEIGVSDPEKVGDGMNAYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLESSELPR SNX2_PONPY Others 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). FDIEIGVSDPEKVGDGMNAYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLESSELPR SNX3_ASHGO Yeast 1 FUNCTION: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). VEVRDPRTHFPHGDSNRGMYTDYLVVCRTNLPSFPQRVSHVRRRYSDFEFFKRCLFKELSLSAHPRVVIPALPGKILWARRFHDEVIEERREGLAQWLSTVAGHPLLQSGSKVLVRFLQDEVFN SNX3_ASPFU Others 1 FUNCTION: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). NFLEIEVRNPQTHGTSRNMYTSYEIVCRTNIPAFKLKHSVVRRRYSDFEYFRDILERESTRVTIPPLPGKVFTNRFSDDVIEHRREGLQRFLQIVAGHPLLQTGSKVLASFIQGELSS SNX3_ASPOR Others 1 FUNCTION: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). NFLEIEVRNPQTHGTSRNMYTSYEIVCRTNIPAFKLKHSVVRRRYSDFEYFRDILERESTRVTIPPLPGKVFTNRFSDDVIEHRREGLQRFLQIVAGHPLLQTGSKVLASFIQDPNWD SNX3_CANAL Yeast 1 FUNCTION: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). NFLEIEVKNPLTHGYGSNLFTDYEIVCRTNIPAFKKRESRIQRRYSDFVAFRKILEQETTRVIIPPLPGKIFLNSNKFNDLNIEKRRQGLEKFLIVVSGHPLLQTGSKSLIEFIQNEKWDP SNX3_CANGA Yeast 1 FUNCTION: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). IEVRNPKTHVPNGVDQRGMYTDYEIICRTNLPNFHKRASRVRRRYSDFEFFRKCLLKEISMLNNPRVVVPHLPGKIYLSNRFSDEVIEERRQGLNRWMQIVAGHPLLQSGSKTLIRFIEDDKFV SNX3_CRYNE Others 1 FUNCTION: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). SFLEIEIRNPMTHGIGRKMYTDYEIVCMTNIPAFKLRHSAVRRRYSDFEAFRDILERESTRVNIPPLPGKVRVFTNRFSDEVIEQRREGLQRFLEIVAGHPLLQTGSKVLCAFLQDPAWD SNX3_GIBZE Others 1 FUNCTION: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). NFLEIEVRNPRTHGMGRHMYTDYEILCRTNIPAFKLRQSSVRRRYSDFEYFRDILERESARVTIPPLPGKVFTNRFSDDVIEGRRAGLEKFLKIVVGHPLLQTGSKVLAAFVQGEFVI SNX3_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking. NFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIID SNX3_KLULA Yeast 1 FUNCTION: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). EIEVCNPKTHFPSGDAKGMYTDYEIICRTNLPGFSKRSSSVRRRYSDFELFRKLLIKELQLSNHPKVSVQHLPGKILLSNRFSDAVIEERRQGLNKWLASVAGHPLLQTGSKVLVRFIQDPTFQ SNX3_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). NFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRHVPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIID SNX3_NEUCR Others 1 FUNCTION: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). NFLEIEVRNPRTHGIGRHMYTDYEIVCRTNIPAFKLRQSTVRRRYSDFEYFRDILERESARVTIPPLPGKVFTNRFSDDVIEGRRAGLEKFLKIVVGHPLLQTGSKVLAAFVQDPNWD SNX3_PONPY Others 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). NFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIID SNX3_SCHPO Yeast 1 FUNCTION: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). NILEIDVINPQTHGIGRNMFTTYEIVCRTNMPYFRLHNSSVRRRYSEFEKFHDMLERESGRVSIPPLPGKIFTQRFRDDVIEERRQGLENFLRLVAGHPLIQTHSRVLSSFLQSPEFK SNX3_USTMA Others 1 FUNCTION: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). NFLEVEVRSPLTHGVGRKMYTDYEIVTRTNIPAFKLRYSSVRRRYSDFEYFRDILERESTRVNIPPLPGKVFTNRFTDEVIEARREGLERFLQVVAGHPLLQTGSKVMAAFLQDSGWS SNX3_YARLI Others 1 FUNCTION: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). NFLEIEVRSPQTHGIARKMYTDYEIVCRTNIPVFKLKSSVVRRRYSDFECFREILERESTRVSIPSLPGKVFTNRFSDEVIEARREGLEKFLQTVAGHPLLQTGSKVLCAFIQDPQWD SNX3_YEAST Yeast 1 FUNCTION: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. SUBCELLULAR LOCATION: Cytoplasm. Mainly. Membrane; peripheral membrane protein. A minor amount associates with membranes. IEVHNPKTHIPNGMDSKGMFTDYEIICRTNLPSFHKRVSKVRRRYSDFEFFRKCLIKEISMLNHPKVMVPHLPGKILLSNRFSNEVIEERRQGLNTWMQSVAGHPLLQSGSKVLVRFIEAEKFV SNX4_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking. SVSEAEKRTGRNAMNMQETYTAYLIETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLFLTQEGNW SNX4_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). SVSEAEKRTGRNAVNMQETYTAYLIETRSVEHADGQSVLTDSLWRRYSEFELLRNYLLVYYPHVVVPPLPEKRAEFVWHKLSADNMDPDFVERRRVGLENFLLRVASHPVLCRDKIFYSFLTQEGNW SNX4_PONPY Others 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). SVSEAEKRTGRNAMNMQETYTAYLIETRSIEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRIASHPLLCRDKIFYLFLTQEGNW SNX5_BOVIN Others 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). LNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDL SNX5_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking. LNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDL SNX5_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). LNVDPSLQIDIPDALSERDKVKFTVHTKTTLSTFQSPEFSVTRQHEDFVWLHDTLTETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSTHEVFLQRLSSHPVLSKDRNFHVFLEYDQDL SNX6_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking. LQSDAALQVDISDALSERDKVKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHVFLEYNQDL SNX6_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). LQSDAALQVDISDALSERDRVNFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRKDLNFHVFLEYNQDL SNX6_PONPY Others 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). LQSDAALQVDISDALSERDKVKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRKDLNFHVFLEYNQDL SNX7_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking. KDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVRRRYQDFLWLKGKLEEAHPTLIIPPLPEKFIVKGMVERFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQAWEL SNX7_MACFA Others 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). KDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVRRRYQDFLWLKGKLEEAHPTLIIPPLPEKFIVKGMVERFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQAWEL SNX7_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). KDLFITVDAPESHVTTIETFITYRIVTKTSRGEFDSSEFEVRRRYQDFLWLKGKLEEAHPTLIIPPLPEKFIVKGMVERFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKVFLTAQAEEL SNX8_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). ARDTVQVELIPEKKGLFLKHVEYEVSSQRFKSSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGADREFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSGSD SNX8_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). AKDTVQVELIPEKKGLFLKHVEYEVSSQRFKSSVYRRYNDFVVFHEVLLHKFPYRMVPALPPKRVLGADREFIEGRRRALKRFINLVARHPPFSEDVLLKLFLSFSGSD SNX9_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking. FDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRDEKE SNX9_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking. FDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVVSESEVFQQFLNFRDEK VPS5_SCHPO Yeast 1 FUNCTION: Required for efficient sporulation Target of PtdIns(3)P in vesicle transport required for onset of the forespore membrane formation. TPFYIQVHDPHTVKEITKSHTVYSVSTRLEEHNQPSVSNVTVQRRYNDFAFLYQLLSNNHPGCIIPPIPEKQVVGRFDDEFIEQRRAALEVMLRKISAHPVLRDDYSFKLFLEAETFD VPS5_YEAST Yeast 1 FUNCTION: Required for retention of late Golgi membrane proteins and vacuolar biogenesis. SUBCELLULAR LOCATION: Cytoplasm. VAFKVEVKDPVKVGELTSIHVEYTVISESSLLELKYAQVSRRYRDFRWLYRQLQNNHWGKVIPPPPEKQSVGSFKENFIENRRFQMESMLKKICQDPVLQKDKDFLLFLTSDDFSS PLDP1_ARATH Mouse 1 FUNCTION: Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond. Phosphatidylcholine-selective. PKAVIVSVSRPDAGDISPVLLSYTIECQYKQFKWQLVKKASQVFYLHFALKKRAFIEEIHEKQEQVKEWLQNLGIGDHPPVVQDEDADEVPLHQDESAKNRDVPSSAALPVIRPLGRQQSISVRGKHAMQEYLNHFLGNLDIVNSREVCRFLEVS PLDP2_ARATH Mouse 1 FUNCTION: Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond. Phosphatidylcholine-selective. PKAAIVSVSRPDTTDFSPLLLSYTLELQYKQFKWTLQKKASQVLYLHFALKKRLIIEELHDKQEQVREWLHSLGIFDMQGSVVQDDEEPDDGALPLHYTEDSIKNRNVPSRAALPIIRPTIGRSETVVDRGRTAMQGYLSLFLGNLDIVNSKEVCKFLEVS TCGAP_HUMAN Human 1 FUNCTION: May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity). FGHIQLLLSPDREGPSLSGENELVFGVQVTCQGRSWPVLRSYDDFRSLDAHLHRCIFDRRFSCLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMEL TCGAP_MOUSE Mouse 1 FUNCTION: May be involved in several stages of intracellular trafficking (By similarity). Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin- stimulated glucose transport. SUBCELLULAR LOCATION: Translocates to the plasma membrane in response to insulin in adipocytes. FGHIQLLLSPEREGPSLSGENELVFGVQVTCQGRSWPVLRSYDDFRSLDAHLHRCIFDRRFSCLPELPPPPEGTRAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMEL BEM1_YEAST Yeast 0 FUNCTION: Necessary for cell polarization during vegetative growth. May link the cytoskeleton to morphogenic determinants on the cell surface. VDGELLVKASVESFGLEDEKYWFLVCCELSNGKTRQLKRYYQDFYDLQVQLLDAFPAEAGKLRDAGGQWSKRIMPYIPGPVPYVTNSITKKRKEDLNIYVADLVNLPDYISRSEMVHSLFVVLNNGF MDM1_YEAST Yeast 0 FUNCTION: Essential for mitotic growth. Mediates organelle inheritance. SUBCELLULAR LOCATION: Cytoplasm. NAQIGKELESIVNLIIKDFVQPWFTKIDKNSDAEFLKVIKWRLLQTLLVVKDKLMKNDSASLIVLKLLPIFNKHFSTFCDAREAVLSDLTLERHKSANIDLQIAVEFNKNYKIHKSLSLKPNALQKEIEKSIRKTVIGLLPHLFDNDELDSLLVFTLMTEVLTTCIISPLIFKFTDPDSWNLRIVSLSQ TKIYIRSYFSENSSNGLKEITYYIINIHHFNNGQVSSWDMARRYNEFFELNTYLKKNFRDLMRQLQDLFPSKVKMSLKYHVTKTLLYEERKQKLEKYLRELLSISEICEDNIFRRFLTDPTPFK MVP1_ASHGO Yeast 0 FUNCTION: Required for vacuolar protein sorting (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). AKNIVVVEEIPEREGILFKHTNYLVKHLVVLPNTNPSSNQTVIRRYSDFNWLQEVLLKKYPFRMIPELPPKKIGAQNADPIFLARRRKGLCRFINLVIMHPVLKQDDLVLTFLTVPTDLG MVP1_ASPFU Others 0 FUNCTION: Required for vacuolar protein sorting (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). EETVTVNLLPEKEGMFMFQHRNYEVKSSRRGSTVIRRYSDFVWLLDCLQKRYPFRQLPLLPPKRIAADSNSFLEKRRRGLVRFTNALVRHPVLSQEQLVVMFLTVPTEL MVP1_ASPOR Others 0 FUNCTION: Required for vacuolar protein sorting (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). EEHVTVTLLPEKEGMFMFQHRNYEVKSARRGSTVVRRYSDFVWLLDCLQKRYPFRQLPLLPPKRLSADSNAFLEKRRRGLVRFTNALVRHPVLSQEQLVIMFLTVPTEL MVP1_CANAL Yeast 0 FUNCTION: Required for vacuolar protein sorting (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). GIDLIKIKEVPEKEGIIFKHINYMITHDLKIGGTSSGTKKVIRRYSDFVWLMEYLLEKYPFRVIPGLPPKKFTVGASPDSQFLQRRRRGLHRFLNQLIKHPILSQEPIVQSFLTVPTDLT MVP1_CANGA Yeast 0 FUNCTION: Required for vacuolar protein sorting (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). QLDIISIEEIPEREGLLFKHANYSVKHLIDLPNTEPPKNRTVVRRYSDFLWLQEVLLKRYPFRMIPDLPPKKIGSQNLDPVFLNKRRIGLSKFINLVMKHPKLSKDDLVLTFLTVPTDLT MVP1_CRYNE Others 0 FUNCTION: Required for vacuolar protein sorting (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). WKDQERIVVTLIPEKEGWFLQKYRIESDKRGEGPVARRYSDFVWLMDVLEKRYPFRILPPLPPKRINPSSAFLEARRLALIRLLSFLTAHPVLRTDACLNIFLTSSSFE MVP1_KLULA Yeast 0 FUNCTION: Required for vacuolar protein sorting (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). AEDIVSVEEIPEREGLVFKHTNYLVKHLTPLPNTDPSDDRTVVRRYSDFDWLQDVLLRKYPFRMVPELPPKKIGSQNADPLFLAKRRKGLSRFINLVMKHPVLRSDDLVLTFLTVPTDL MVP1_NEUCR Others 0 FUNCTION: Required for vacuolar protein sorting (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). EENILVTLMPEKEGVFMFQHHNYEVSSIRRGSKVVRRYSDFVWLLDCLHKRYPFRVLPLLPPKRVASFIEKRRRGLARFLNALVRHPVLGQEQLVIMFLTVPTEL MVP1_SCHPO Yeast 0 FUNCTION: Required for vacuolar protein sorting (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). TSFPASLEMNVDIDLEPSGYFFYRHNNYIISDSSNTREVLRRYSDFFWLHSYLMKKYPFRRVPLIPLKKFHSKCFNSKQFFRTPPPGLSDFVNDLSHHPIFSNDEVVRVFFTEPNVF MVP1_USTMA Others 0 FUNCTION: Required for vacuolar protein sorting (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). PEDQVTVRLRSELEGFIIKHNVYIVSSSLRKSQVTRRYSDWLWLAECLVKRYPFRCLPVLPPKRIAMPIAGRHLSADDLFIERRRRGLERFLRMLTCHPMLREDKLVEVFFTEPRPI MVP1_YARLI Others 0 FUNCTION: Required for vacuolar protein sorting (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). ADSVTLAIVPEREGMFLFRHVNYSISSVSGTDRITVIRRYSDFSWLQDYLLKKYCFRQVPLLPPKRLAVNGHYLSSDNYFLERRRRGLTRFINQVLRHPVLGQDEAVRTFVTLRNDIS MVP1_YEAST Yeast 0 FUNCTION: Required for vacuolar protein sorting. SUBCELLULAR LOCATION: Cytoplasm. DADIIIIEEIPEREGLLFKHANYLVKHLIALPSTSPSEERTVVRRYSDFLWLREILLKRYPFRMIPELPPKRIGSQNADQLFLKKRRIGLSRFINLVMKHPKLSNDDLVLTFLTVRTDLT NCF4_HUMAN Human 0 " FUNCTION: Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex." SUBCELLULAR LOCATION: Cytoplasm. DVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPDSKSSALACTLPTLPAKVYVGVKQEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDS NCF4_MOUSE Mouse 0 " FUNCTION: Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex." SUBCELLULAR LOCATION: Cytoplasm. DVAVSANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFYALQSKLEERFGPESKNSPFTCNLPTLPAKVYMGAKQEIAETRIPALNAYMKNLLSLPVCVLMDPDVRIFFYQSAYDA SCD2_SCHPO Yeast 0 FUNCTION: Required for mating and morphogenesis. Interacts directly with scd1 and with cdc42. May bridge and facilitate scd1 and cdc42 interactions. SSEPTVVAAMVENYMIRDDQYWYLVRAVMSDGKHRNLCRYYEDFFNFQTKFLELFPNEAGRGDERRVIPYMPGPVDDVNELISSQRAMDLDVYLKEMCRLPARLLENELVKLFFLPLDGDV VAM7_YEAST Yeast 0 FUNCTION: Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure. SUBCELLULAR LOCATION: Vacuole. MAANSVGKMSEKLRIKVDDVKINPKYVLYGVSTPNKRLYKRYSEFWKLKTRLERDVGSTIPYDFPEKPGVLDRRWQRRYDDPEMIDERRIGLERFLNELYNDRFDSRWRDTKIAQDFLQLSKPN YHQ5_YEAST Yeast 0 FQKAHVSDCTIVNGDHGTKFAVWRITVFLEPNLKAFAAKRESYKIQTYKRYSDFVRLRENLLTRIKTAKPEKLNCLQIPHLPPSVQWYSSWKYQEVNLNKDWLAKRQRGLEYFLNHIILNSSLVEMTKDILIQFLEPSKRV YTDK_CAEEL Others 0 HVDVPDTKTLVERSDGITKYTAYNIHINGWYHGSVRFSHLYEFAELIKQKFSQRYKGPEFPAKKLFKLDPKAIDERRQKITKYFQALVQHPEVARHYLVEKKLLGFQIDS SPO14_YEAST Yeast 0 " FUNCTION: Required for meiosis and spore formation. Seems to be involved in the coordinate induction of late meiotic events. PLD activity is induced under sporulation conditions and seems to be necessary to complete the meiotic cycle, but not for vegetative cell growth." MYSRNENSLFRIHLEYGIDEDRLKWSIIRSYKDIKSLHHKLKIVAFQQLTISKLYSDNNRYHSLQLPHFPHYKEMVKERNVMEKKAENKPSSAASAPHTSENNNNDNGSNITSLETLSSSEISEFNIDNVKMKHLQDLIDEPDDFSQPIHLRLERYLRLLNIALCLRPHANRLFEFYELS YA2G_SCHPO Yeast 0 TDLIKVSVLDVEPKHNRIHSTFTIQVEYGTGPHAIRWLIYRQLRDFINLHSHFLFFEFQHRFSGRRMKLPKFPKEVLPYLVKLRGYQKILYSNPSDQLIDETHSISDISWESHSQDGDRTTGQPRHANNGRKKHGNFWTIQGNTLGVYLQEMIHNLQFFPEVNVLYSFLEFS