Bioe 480 : Introduction to Bioinformatics

Fall, 2006
Meet every Tuesday and Thurday 9:30am - 10:45am 419 CMW 419

Midterm exam: Oct 19, 2006. In class. Close book exam.

Instructor: Hui Lu
820 S. Wood
Room W103, M/C 563,
Chicago, IL 60612-7340
Telephone: 312-413-2021
Email: huilu@uic.edu

TA: Nitin Bhardwaj

Room W103, 835 S Wolcott.
Telephone: 312-413-2015
Email: nbhardwaj@gmail.com


Reference Book: Biological Sequence Analysis: Probablisitic models of proteins and nucleis acids by R. Durbin, S. Eddy, A. Krogh and G. Mitchison



Announcement: Seminar titled Final Project: Due Dec 8th, 2006.



The schedule below is a tentative one and is subject to changes.

Date

Content

References

Homework

Solution

Aug 29

Lecture 1: Introduction -- bioinformatics topics and molecular biology. Slides.

 

 

 

Aug 31

Lecture 2: Introduction to Molecular Biology part 2. Slides.

Ch 2 and others

 

 

Sept 5

Lecture 3: Programming and databases in bioinformatics. Slides. Slides.

Ch 3

 

 

Sept 7

Lecture 4: Pairwise Sequence Alignment. Slides

Ch 3

Homework1 (due on Sept 14 before class)

Solution 1

Sept 12

Lecture 5: Scoring Matrix. Slides  

Ch 3

 

 

Sept 14

Lecture 6: Multiple Sequence Alignment

Slides

Ch 3

 

 

Sept 19

Lecture 7: Statisticalmethods in sequence analysis

Slides

Ch 3

Homework 2 Due on Sept 28th before class

Solution 2

Sept 21

Lecture 8: Hidden Markov Models Slides

Ch 3

 

 

Sept 26

Lecture 9: Hidden Markov Models on Sequence Analysis Slides

 

 

 

Sept 28

Lecture 9: Hidden Markov Models on Sequence Analysis Slides

 

 

 

Oct 3

Lecture 10: Statistical methods in bioinformatics/sequence analysis Slides

 

 

 

Oct 5

Lecture 10: Statistics in sequence analysis (Lecture cancelled due to the Workshop)

NCBI Workshop

Homework: Attend atleast one traning session during the workshop and write a one-page report about it

 

Oct 10

Lecture 11: Database search Slides

1.5 lecture

 

 

Oct 12

No class; BMES Chicago

 

 

 

Oct 17

Review session.

 

 

 

Oct 19

Midterm Exam.

 

 

 

Oct 24

Lecture 12: Microarray analysis Slides

 

Homework 3 (Due Nov 2 before class)

Solution

Oct 26

Lecture 13: Phylogenetic analysis Slides

 

 

 

Oct 31

Lecture 14: Phylogenetic analysis 2 Slides

 

 

 

Nov 2

Lecture 15: Gene Identification Slide

 

 

 

Nov 7

Lecture 16: Whole Genome Analysis Slide

 

Homework 4 Due Nov 16th

 

Nov 9

Lecture 17: Genomic Circuits Slides

gene regualtion sea urchin

 

 

Nov 14

Lecture 18: Protein structure and prediction Slides

 

 

 

Nov 16

Lecture 19: Protein secondary structure prediction and homology modeling Slides

 

 

 

Nov 21

Lecture 20: Protein folding and structure prediction Slides

 

 

 

 

Nov 23

Lecture 20:Protein folding and structure prediction Slides

 

 

 

Dec 5th

Lecture 21:  Drug Design/Discovery and DockingSlides

 

 

 

 

Dec 7th

Project Presentation

Individual presentation for no more than 10 mins. Introduce your protein in 1 or 2 slides followed by results for 7-8 slides. Order of presentation (by last name):Davide Candaro, Adam Carlson, Fabio Cuncure, Andrea Franceschini, Ali Husain, David Jimnez-Morales, Ramkrishna Mehendale, Himanshu Patel, Aishwarya Parmeswaran, Tom Ronan, Gobind Singh.

Homework 5 For Practice (no submission required). Solution will be posted on Dec 8th.

SolutionSomehow I could not get the diagrams to be at the right place (I think it was a tranfer mode problem). You can drag these pictures to the correct place after clicking on any of the edge.

Nov 30

Project Presentation:

 

 

 

Dec 5

Project Presentation:

 

 

 

Dec 7

TBA